These highly concentrated cannabis oils are among the most potent forms of cannabis, with powerful effects even in small doses. Many holistic users take up to 1 gram of full-extract cannabis oil per day, divided into multiple doses. For a single dose, you can take one small droplet of concentrated oil. Repeat 3–4 times per day. Do be mindful that one full gram of concentrated full-extract cannabis oil is already a very high dose. Always consult a medical professional before taking high doses of cannabis.
With most cannabis edibles, a single dose consists of 10mg of either THC or CBD. You can also find products that contain 100mg or more of THC or CBD per dose, although these are normally not actually meant to be taken as a single dose.
Let’s break it down in detail:
6. How to dose transdermal cannabis patches
Microdosing cannabis is a new rising trend among medicinal cannabis consumers. When microdosing, you are taking minimal doses of THC, about 5–10mg per dose, once or several times throughout the day. The idea behind microdosing is that you take just enough THC (known as the “minimum effective dose”) so that you feel the desired effect, but can still function and go about your daily routine.
If you’ve just bought 1g (1000mg) of shatter with 70% THC, the total amount of THC in that piece of shatter is 700mg (or roughly 28 doses). While it’s impossible to divide 1g of BHO into exact 25mg doses, you can use a dab tool to load grain-of-rice-sized doses into your chamber or nail and adjust the amount as needed.
A standard dose when smoking or vaping dry herb is roughly 0.25–0.5g. In fact, most pre-rolled joints sold in legal markets tend to contain roughly 0.5g of dried bud. Using our White Widow Automatic example from above, a 0.5g joint would contain 70 milligrams of THC. If you’re trying a new strain or just starting to consume cannabis, beginning with a 0.25g dose is a great idea. Remember, you can always up your dose if need be.
Full-extract cannabis oils (like Rick Simpson oil, for example) are highly concentrated cannabis concentrates. To calculate the total mg of cannabinoids in your oil, use the following formula:
Manning T, Bartow C, McNaughton M, Reynolds E, Chen Z. Vaping Cannabis Oil: A Case of Catatonia Associated With Use of High-Potency Cannabis. Psychosomatics. 2020;61(6):745-751. View abstract.
Liver disease: It is unclear if cannabis worsens chronic liver disease. While some weak evidence suggests that there might be a link, other evidence has not found a link. Until more is known, be cautious using cannabis.
Guzman, M. Cannabinoids: potential anticancer agents. Nat.Rev.Cancer 2003;3(10):745-755. View abstract.
Schizophrenia: Using cannabis might make symptoms of schizophrenia worse.
Voci S, Zawertailo L, Baliunas D, Masood Z, Selby P. Is cannabis use associated with tobacco cessation outcome? An observational cohort study in primary care. Drug Alcohol Depend. 2019 Nov 20;206:107756. View abstract.
Chemical structures of (A) Δ 9 -THC, (B) CBD, (C) Δ 9 -THCA, and (D) CBDA. THCA, tetrahydrocannabinolic acid.
1 Center for Molecular Design and Preformulations, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
2. Sonication. Hemp seeds (1 g) were macerated, reweighed, and then transferred to a beaker. The macerated seeds were suspended in ethanol (26 mL), and the suspension was sonicated for 20 min after which the solvent was decanted. The sonication was repeated two additional times, collecting the solvent by decantation, refilling with an equivalent amount of solvent, and a 10-min break between each sonication session. All decanted solvent fractions were combined and filtered on a pad of Celite (1 g) and activated carbon (0.25 g). The solids were washed with additional solvent and concentrated to dryness under reduced pressure at 25°C to obtain a sticky resin (yield: 23–40%).
Commercial hemp seeds are marketed for their high nutritional values, but due to their relationship to Cannabis spp. of plants, there is a potential for the presence of phytocannabinoids in these seeds. By regulation, total amount of Δ 9 -THC (whether in its acid form, Δ 9 -THCA, or as neutral Δ 9 -THC) must be less than 10 μg/g of hemp seeds (10 ppm) in Canada, and similar regulations exist in other countries where hemp seeds are legal. Hemp seeds from three brands in local supermarkets were purchased and brought to the laboratory. Each brand of hemp seeds was subjected to four different extraction protocols, and each protocol was repeated thrice to account for any variability due to the extraction procedures and associated errors. In total, 36 extracts were obtained from the three brands and analyzed using UPLC-mass spectrometry to quantify the two major phytocannabinoids, Δ 9 -THC and CBD. We expected the quantity of Δ 9 -THC to be within the regulation limits and CBD to be in relatively higher quantities, as one would expect in hemp seeds. As it is common in the Cannabis spp. plants, majority of phytocannabinoids such as Δ 9 -THC and CBD exist in their carboxylic acid precursor forms, Δ 9 -THCA and CBDA ( Fig. 1 ). Subjecting the extract or resin to high degree of temperature converts these acid precursors into decarboxylated forms, Δ 9 -THC and CBD. However, we calculated the total Δ 9 -THC equivalency (including Δ 9 -THCA and Δ 9 -THC found in each extract) to assess the total concentrations; similar procedure was used for the total concentration of CBD.
Sample injection volume was 10 μL, at a mobile phase flow rate of 0.6 mL/min for a total run time of 6 min. Two mobile phases, water/0.1% formic acid (phase A), and methanol/0.1% formic acid (phase B), were used and gradient conditions were used for elution: 0–4.5 min: 30%→0% phase A and 70%→100% phase B, 4.5→5 min: 100% phase B, and 5→6 min: 30% phase A and 70% phase B. Internal standard was benzophenone (10 μg/mL solution in MeOH), and each sample was spiked with 9.6 μL of internal standard before analysis. Each sample was analyzed in triplicate.
According to Health Canada’s Industrial Hemp Technical Manual, the current approved procedure of Δ 9 -THC quantification in hemp involves the sonication of 3 g of dried leaf powder in hexanes followed by analysis by gas chromatography. 11 There is no mention of testing procedures for any other parts of the hemp plant, including its seeds. Using a similar hexane-sonication procedure, quantification conducted by Ross et al., obtained Δ 9 -THC concentrations of 0–12 μg/g for fiber-type cannabis seeds. 7 In this study, ethanolic extraction using sonication exhibited significant variation from 17% to 92% of the maximum yield across the three brands of hemp seeds. This inconsistency could be attributed to the higher oil content within hemp seeds compared to the rest of plant. Due to hydrophobicity of the Δ 9 -THC molecule, it is expected to partition more strongly into the seed material, leading to the gross underestimation of Δ 9 -THC content by sonication.
In an earlier study, Ross et al. conducted an investigation to determine Δ 9 -THC content in drug- and fiber-type (hemp) cannabis seeds. 7 Hemp seeds in this study were found to contain 0–12 μg Δ 9 -THC per 1 g of seeds, but Δ 9 -THC in drug-type cannabis seeds was in much higher levels (35.6–124 μg/g). It was found that majority of Δ 9 -THC was located on the surface of the seeds, and a wash with chloroform removed upto 90% of Δ 9 -THC. It was suggested that fluctuations in the Δ 9 -THC content of different replicates of the same type of seeds could be the result of the degree of contamination on the outside of the seeds. In this study of consumer-grade hemp seeds acquired from the grocery stores, highly variable, but above the legal limit of, Δ 9 -THC may suggest either contamination by drug-type cannabis seeds or improper washing of the seeds.