CBG vs CBD: Detailed Breakdown and Best Products Cannabinoids are the chief chemical compounds found in the cannabis plant that interact with the body’s endocannabinoid system—the complex network of cannabinoid receptors that influence the central nervous system and immune system, among others. While CBD and THC often steal the show when it comes to the powerful ch
CBG vs CBD: Detailed Breakdown and Best Products
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CBD and THC are definitely two of the most well-known cannabinoids. CBD is known for its calming, therapeutic effects while THC is famous for its psychoactive effects that cause feelings of euphoria and sometimes confusion. While CBD and THC have both had plenty of time in the spotlight, lesser-known cannabinoids, such as CBG, are capturing interest from consumers and scientists alike.
Initial studies show that CBG may have similar characteristics of CBD. Both of these cannabinoids have no psychoactive properties. Instead, they offer antioxidant, anti-inflammatory, neuroprotective, and analgesic properties.
Here’s what you need to know about the similarities and differences between CBG and CBD. We’ll also take a look at some of the top CBD products on the market.
What is CBG?
CBG, which stands for cannabigerol, is one of more than 100 cannabinoids found in hemp and cannabis plants. Young hemp plants produce cannabigerolic acid (CBGA). As the plant matures, CBGA breaks down into cannabidiolic acid (CBDA) and tetrahydrocannabinolic acid (THCA). These two compounds are then converted into CBD and THC. Any leftover CBGA is converted into CBG.
Even though CBG was first isolated back in 1964, the cannabinoid didn’t get a lot of attention, so there are very few studies about the compound. Modern research is in preclinical stages, but from what we know so far, CBG may have various therapeutic side effects.
It’s possible that CBG has strong pain-relieving properties that may be more effective than THC. CBG may interact with the CB1 and CB2 receptors of the endocannabinoid system, which influence inflammation, pain, and even heat sensitivity. The cannabinoid may also have antidepressant, anticancer, and antibacterial qualities.
What is CBD?
CBD, which stands for cannabidiol, naturally occurs in high concentrations in hemp and cannabis plants. CBD was first isolated all the way back in the 1930s but was mostly put aside until the 1970s when scientists determined it may be an effective anti-convulsant.
Over the years, research has confirmed many of the therapeutic benefits that CBD offers, including anti-anxiety, pain-relieving, anti-nausea, and sedative qualities. CBD has also shown to be an effective treatment for severe forms of childhood epilepsy and is used in an FDA approved drug, Epidiolex.
Over the last few years, CBD has become the cannabinoid of choice, not only for the many therapeutic benefits it offers, but also because it has no psychoactive properties. Unlike THC, CBD offers pain relief and other benefits without the risk of paranoia, anxiety, or impaired cognitive function.
Like CBG, CBD interacts with the CB1 and CB2 receptors.
Differences Between CBG & CBD
Though they offer very similar therapeutic properties, CBG and CBD do have some differences. For example, the two cannabinoids have different molecular structures. This means that the arrangement of carbon, hydrogen, and oxygen is different. Molecular structure impacts how the cannabinoid binds with receptors and also impacts bioavailability.
CBG and CBD are also unique in how they activate receptors. One study looked at how CBG and CBD interact with the 5-HT1A serotonin receptor . CBG behaves as an antagonist at that receptor, where CBD has strong anti-nausea effects, which means it acts like an agonist.
So even though the two cannabinoids are similar, when bound to the same place, they have opposing effects on this specific receptor.
CBG and CBD differ in how they stimulate the appetite. A study conducted on rats found that CBG encouraged the animals to eat two times their normal food intake. But, a study conducted on CBD found that the cannabinoid significantly reduces total food intake .
Therapeutic Benefits of CBG vs CBD
There isn’t a lot of research that has delved into the therapeutic effects of CBG. However, preclinical studies offer a little bit of insight as to how the cannabinoid may interact with the body. Like CBD, CBG doesn’t have any psychoactive properties. Instead, it offers other therapeutic benefits, including:
● Potential treatment for MRSA bacterial infections
As interest in CBG continues to grow, we can expect to learn more about the cannabinoid over the next few years. The hope is that more clinical studies and research will be conducted so that we can get a better understanding of the benefits that CBG offers.
CBD is in a similar situation, but there are far more studies that have been conducted. Research has found that CBD offers a host of therapeutic benefits, including:
● Lowered stress and anxiety
But as with any cannabinoid, there is always more to learn. Most studies have been conducted on animals, so human trials are crucial to fully understand how CBG and CBD interact in the body.
Are you interested in trying CBD, CBG, or maybe a product that contains both? Here are some of the best hemp-derived products available on the market today.
Top 4 CBD Products
Penguin is another top brand that we highly recommend. They offer some of the purest and most potent CBD products on the markets. With a well-rounded selection of products, you’re sure to find the CBD that best meets your lifestyle needs. Choose from gummies, oils, topicals, and capsules.
Penguin only uses the best ingredients, including broad-spectrum CBD oil that is extracted from Oregon grown hemp. Because these products contain no THC, you can enjoy peak mental performance while also enjoying the many therapeutic benefits that CBD has to offer.
What’s even better is that the brand offers some delicious flavors. Penguin’s CBD gummy worms are coated in a tangy sugar that will make your taste buds go wild. There’s also deliciously flavored CBD oil, including options such as Cookies & Cream, Citrus, Strawberry, and Mint.
2. Verma Farms
Verma Farms is one of the highest-quality CBD brands that we’ve found. All of their products are made with top notch ingredients that are organic and all natural. They offer an extensive collection of items to choose from, including gummies, oils, capsules, topicals, and even tropical dried fruit!
Verma Farms uses broad spectrum extract, which contains all of the wellness-boosting plant compounds, with the exception of THC. This means you can enjoy the benefits of minor cannabinoids, terpenes, flavonoids, and fatty acids!
This is a brand that takes a Hawaiian approach to making CBD. All of their products are influenced by the islands, so you can drift off to your own tropical paradise.
3. BATCH CBD
Organically grown and highly effective, BATCH CBD’s products are deeply therapeutic and create lasting benefits for both the body and the mind. Whether you are seeking a better night’s sleep, a way to ease day-to-day stress, or a natural approach to relieve pain and inflammation, BATCH has got you covered.
BATCH CBD prioritizes product quality and customer service to deliver truly life-changing results. From seed to shelf, the BATCH team carefully manages every aspect of their product development, ensuring that each and every product is sustainably crafted with ingredients of the highest quality.
BATCH has an incredible line of CBD products, including their CBG Oil , which includes a 1:1 CBD to CBG ratio . Made with a vegan formula and flavored with citrus extracts, BATCH’s CBG Oil tastes great and offers the substantive benefits of both CBD and CBG!
4. Colorado Botanicals
Colorado Botanicals once again makes our top spot. Despite years of product innovation from its competitors – they stay ahead of the curve with superior quality and some of the most potent CBD oils, capsules, topicals, and gummies on the market.
Initially offering broad-spectrum CBD extracts, Colorado Botanicals recently added full-spectrum CBD oils and several CBG products enhanced with a clinically studied curcumin ingredient and Boswellia. With so much variety and customizability, there’s something for every health-conscious shopper.
Colorado Botanicals is unique in that they can naturally retain terpenes and flavonoids thanks to their proprietary extraction and purification process. The end product is a highly pure and concentrated product without any impurities. Also, their products are constantly tested for contaminants such as heavy metals, pesticides, solvents, and microbes.
5. Extract Labs
Extract Labs is known for providing the purest, highest-quality CBD products at the lowest price, a promise which is made possible by keeping every step of production in-house. Few companies offer CBG products because it is difficult to extract and not as abundant as CBD. Extract Labs offer an extensive collection of CBG products, including full spectrum CBG oil, a THC free CBG tincture, CBG isolate, CBG softgel capsules and CBG gummies. CBG gummies are one of their most popular products, with 33mg CBG and 33mg CBD apiece – they are made with natural ingredients and quality broad spectrum hemp oil. They also have a vast array of high-quality CBD products to try.
6. Joy Organics’ USDA Certified Organic CBG and CBD Tincture
Joy Organics is one of the first CBD oil tinctures on the market to be made entirely of USDA Certified Organic ingredients. This is a brand that doesn’t compromise on quality, using only the highest quality ingredients such as broad and full spectrum CBD, along with organic MCT oil, stevia, and oil-based flavoring.
Joy Organics continues to expand its USDA Certified Organic CBD tinctures with their new CBG and CBD tincture. Their CBG + CBD Tincture contains two hemp-derived compounds to support homeostasis in the body. CBG is known as the “mother of all cannabinoids” and works synergistically with CBD to support mental and physical wellness.
In addition to this tincture, Joy Organics offers a wide array of both full and broad spectrum products that focus on clean and organic ingredients along with extensive lab testing for purity. These products include
Gummies (full and broad spectrum)
Delta 9 products
CBD and CBG are two similar yet unique cannabinoids. While hemp plants contain a much higher dose of CBD, CBG can also be extracted and used in all sorts of products. These two cannabinoids offer a variety of therapeutic benefits, and when combined, can provide highly effective relief that keeps you feeling your best.
8 Benefits of CBDA and CBGA
Cannabinoids are the chief chemical compounds found in the cannabis plant that interact with the body’s endocannabinoid system—the complex network of cannabinoid receptors that influence the central nervous system and immune system, among others. While CBD and THC often steal the show when it comes to the powerful chemical compounds associated with the cannabis sativa plant, they aren’t the only cannabis-related chemicals with tremendous health and wellness potential.
Recent data featuring both CBDA and CBGA, additional cannabis compounds, have yielded exciting results for their future in helping patients support overall good health. While research remains in very early stages, it seems reasonable to expect good things from both CBDA and CBGA in terms of health support in the future.
8 Benefits of CBDA and CBGA
- Potentially Effective Against SARS-CoV-2 (COVID-19)
- Supports Cardiovascular Health
- Regulates Metabolism
- Anti-Anxiety and Depression Properties
- Prevents Seizures
- Boasts Anti Inflammatory Properties
- Effective Anti-Nausea Agent
- Potential Cancer Treatment
The cannabis sativa plant is one of the world’s oldest cultivated crops, and boasts a long history of human extraction and consumption in many different forms. In recent years, various chemical compounds found in the hemp plant and the cannabis sativa plant have garnered attention for their wide and varied documented health benefits.
Essentially, phytocannabinoids found in cannabis and hemp plants exist in two different states: either acidic, like THCA and CBDA, or neutral, like THC and CBD. But while neutral cannabinoids like THC and CBD, which have been extensively studied over the past four decades, typically have been viewed as the chief therapeutic compounds in the cannabis plant, some emerging data suggest that there may be a benefit to using the raw plant—gaining the benefits of acidic phytocannabinoids in the plant, including CBDA and CBGA. While the scientific world identified these compounds more than 50 years ago, it’s only recently that they have garnered interest for their therapeutic effects.
What Are CBDA and CBGA?
Cannabidiolic acid (CBDA) and cannabigerolic acid (CBGA) are lesser-known compounds found within the raw cannabis sativa plant, both of which may have exciting effects on the world of health and wellness based on early-stage recent research. In fact, some experts consider these compounds the next frontier when it comes to cannabinoid-based therapy—expanding the potential development of medications that are not only more therapeutically effective, but also less likely to cause unwanted side effects and/or long-term dependency than current options.
CBGA is a foundational compound of the raw cannabis flower, formed in the cannabis plant when geranyl pyrophosphate and olivetolic acid combine. The resulting enzymatic reaction converts CBGA into several different cannabinoids, leading to its sometimes being called the mother cannabinoid. In fact, CBGA is the precursor to three of the most commonly found cannabinoids: tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) and CBDA. These are known as acidic cannabinoids. CBGA (Cannabigerolic acid) holds potential for treating diseases, but more data is needed to support anecdotal claims to suggest CBGA as a treatment option. Some data indicates that CBGA may make the body more receptive to other cannabinoids, plus assisting the body as it processes them. CBGA also has some reported analgesic, anti-inflammatory, antibacterial and anti-proliferative properties.
Through an extraction process called decarboxylation, acidic cannabinoids are converted into their decarboxylated forms, which are the main psychoactive cannabinoids—THC, CBC, CBD, etc.—that positively affect the body and with which most people are familiar with. While THC is the chief psychoactive compound associated with marijuana use, CBD has gained attention in recent years for its many health benefits that come without the mind-altering effects associated with THC. CBD is simply the decarboxylated form of CBDA. Decarboxylation occurs when the cannabis plant is heated, dried or processed.
In most cannabis plants, cannabidiolic acid appears in only small amounts, though hemp oil, in particular, is known for its higher CBDA content. And because it is non-intoxicating, CBDA is completely legal in nearly every state. Additionally, cannabidiolic acid has greater bioavailability; meaning it is absorbed by the body up to 11 times better than CBD when taken orally. There is also some animal-based data that CBDA is, in fact, stronger and more potent than CBD. This appears to be not just because CBDA is absorbed better, but because it actually acts more effectively in the body to address symptoms like nausea and vomiting, pain, inflammation and even seizures.
CBDA’s basic mechanism of action comprises interacting with the endocannabinoid system by inhibiting the Cox 2 enzyme, which is slightly different from how CBD works. In general, a CBD product works by binding to CB1 and CB2 cannabinoid receptors, which produces a slightly different result.
8 Benefits of CBDA and CBGA
Now that we’ve explained what CBDA and CBGA are, let’s take a closer look at some of their chief benefits:
1. Potentially Effective Against SARS-CoV-2 (COVID-19)
In a very exciting recent development, researchers have found that both CBDA and CBGA have some potential to combat the SARS CoV 2 infection (also known as coronavirus). Both compounds seem to block a critical step in the process the virus uses to infect patients.
According to researchers led by scientist Richard Van Breemen at the Linus Pauling Institute at Oregon State University, the two cannabis compounds are able to bind to the spike protein that is characteristic of the virus particles—this then prevents the protein from being able to bind to sites within human cells. This inability to bind effectively prevents a key step that the SARS-CoV-2 virus uses to infect patients.
It’s important to note that all testing thus far has incorporated only the alpha and beta variants of the SARS-CoV-2 coronavirus, not later strains like Delta or Omicron. Even so, researchers remain optimistic that the efficacy of CBDA and CBGA against early variants bodes well for their effectiveness against later iterations of the virus. Further research, of course, is needed, but both chemical compounds show potential as adjunctive therapy to vaccines for both the prevention and the treatment of COVID-19.
2. Supports Cardiovascular Health
More and more data supports the fact that regulating the endocannabinoid system with phytocannabinoids can have positive effects on cardiovascular health. In particular, the chemical compounds found in hemp and the cannabis sativa plant, including CBDA and CBGA, can be effective against cardiovascular issues, including myocardial infarction (heart attack), atherosclerosis, arrhythmias, hypertension, and metabolic disorders.
In particular, blocking CB1 receptors with phytocannabinoids has a tremendously positive effect when it comes to treating cardiometabolic disorders. In addition, one study has shown that CBGA may be effective in helping diabetic patients manage several of the disease’s complications and comorbidities—including cardiovascular disease.
3. Regulates Metabolism
At least one study has indicated that CBGA may help patients manage metabolic disorders. A 2019 computer simulated study revealed that CBGA helped stimulate lipid metabolism, which reduced excess lipid accumulation. Though these early results are promising, more research is needed, particularly studies with animal and/or human subjects.
4. Anti-Anxiety and Depression Properties
While the non-acidic CBD has long been touted as a potential treatment for both depression and anxiety, there is reason for excitement around cannabidiolic acid as well. In fact, researchers have seen that CBDA not only affects the same receptors as CBD—namely, the receptors that control feelings of anxiety and well-being—but that it is effective as an antidepressant at doses 10 to 100 times less than the dosage size required of CBD.
5. Prevents Seizures
Currently, the only FDA-approved CBD medication is an anti-seizure drug called Epidiolex, which is used to treat drug-resistant epilepsy. The manufacturer of Epidiolex also has conducted tests comparing the efficacy of cannabidiolic acid against that of CBD in seizure prevention. Some early data shows that CBDA may demonstrate better bioavailability and a faster-acting effect than CBD. This may mean that smaller doses of CBDA would be needed for effective seizure prevention, even further reducing the chance of any side effects associated with the product.
6. Boasts Anti Inflammatory Properties
While inflammation is a natural and necessary response to trauma, chronic inflammation can be the source of many health issues, not least among them, arthritis. Chronic inflammation is highly influenced by the Cox 2 enzyme. CBDA has shown powerful anti inflammatory properties, and may be effective against inflammation because of its characteristics as a selective Cox 2 inhibitor. This means cannabidiol acid works in much the same way as non-steroidal anti-inflammatory drugs, like aspirin and ibuprofen, but without the damaging long-term side effects to the gastrointestinal tract.
7. Effective Anti-Nausea Agent
Researchers have found that CBDA can be a powerfully effective agent against nausea and vomiting caused by toxins and motion sensitivity. In fact, a 2012 study revealed that CBDA treatment dramatically reduced nausea behaviors in mice. And perhaps most exciting, CBDA has shown promising effects against the anticipatory nausea many patients feel before receiving chemotherapy treatments. Since no current medication has been effective for this type of nausea, CBDA appears especially positive. In some tests, cannabidiolic acid showed an anti-nausea impact at a dosage size 1,000 times smaller than the dose of CBD needed to achieve the same effect.
8. Potential Cancer Treatment
In one preclinical study , researchers found that CBDA could potentially suppress the spread of a specific type of breast cancer cells (cells with a higher-than-average concentration of the Cox 2 enzyme). Specifically, CBDA treatment seemed to prevent the migration of breast cancer cells.
In theory, a therapy that could stop cancer cells from metastasizing would be able to prevent the disease from spreading throughout the body. In addition, in the course of the study, CBDA reduced the effectiveness of the Id-1 protein associated with catalyzing cancer cell growth and survival. CBDA also seemed to increase Sharp-1 expression associated with suppressing breast cancer metastasis. While more research is certainly needed to determine the exact effect of CBDA on cancer, early data indicates it may have great promise to help suppress the spread of harmful cells within the body.
In fact, both CBDA and CBGA have also been reported to demonstrate cytotoxic activity against colon cancer. In fact, CBGA has been shown to kill colon cancer cells, along with hastening early cancer cell death and arresting the cancer cell cycle. While more research is needed in this area, researchers are optimistic that CBGA could effectively target not only colon cancer cells, but could also prevent the growth of pre-cancerous polyps.
Are CBDA and CBGA in CBD Oil?
As it turns out, both CBDA and CBGA are absent from traditional CBD oil, which features neutral CBD compound only. It’s important to remember that the chemical compound of CBD is only produced after the decarboxylation of CBDA, so it’s no longer present in the final CBD product. In fact, CBDA and CBGA are not usually found in most commercial hemp CBD products.
This means you should make note that if you’re using CBD oil, you should not expect to get all the same therapeutic benefits we’ve outlined here; especially when it comes to potentially preventing or treating a COVID 19 infection due to SARS-CoV-2. The promising effects against COVID-19 are specific to CBDA and CBGA. These were the only hemp or cannabis-related compounds that have shown promise against the SARS-CoV-2 virus. So, while CBD won’t magically turn into a COVID-19 prevention or cure, it does offer a full range of other health benefits, including headache relief .
CBDA and CBGA Research Looks Promising
Early research around CBDA and CBGA as medical treatments has shown exciting results, but it’s important to remember that current research has focused chiefly on animal subjects. Until more human clinical trials are conducted, it’s impossible to say for certain how effective these chemical compounds may be against a variety of potential health issues—certainly not least among them, the prevention and treatment of COVID-19.
However, early research shows some exciting and promising potential for these powerful chemical compounds when it comes to safely and effectively treating a variety of health conditions.