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Learn more about cannabichromine, or CBC, a cannabinoid found in the cannabis plant that's showing promise in the lab for a myriad of conditions. By now you’re familiar with popular cannabinoids like CBD. But what is CBC and what does it do?

What Is CBC and What Are the Benefits of This Cannabinoid?

By now you’re probably familiar with cannabinoids, especially the most common ones, THC and CBD. But you likely haven’t heard of cannabichromene, also known as CBC. Discovered over 50 years ago, CBC is considered one of the “big six” cannabinoids prominent in medical research. It doesn’t get as much attention, but CBC’s benefits are extremely promising.

CBC has the same origins as both THC and CBD do in that they all stem from cannabigerolic acid (CBGA). Cannabis plants produce CBGA, the precursor to three major cannabinoids: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA).

The specific plant enzymes cascade and “direct” the breakdown product into one of the three lines. For CBC, it converts from CBGA into cannabichrome carboxylic acid (CBCA), and then finally to CBC after exposure to heat or ultraviolet light.

CBC Works With Other Cannabinoids

CBC is non-intoxicating, so it doesn’t produce a euphoric high like THC. The reason it is non-intoxicating is because it binds poorly to CB1 cannabinoid receptors in the brain. But CBC does bind with other receptors in the body, such as the vanilloid receptor 1 (TRPV1) and transient receptor potential ankyrin 1 (TRPA1), both of which are linked to pain perception. When CBC activates these receptors, increased levels of the body’s natural endocannabinoids like anandamide are released.

While CBC definitely has singular benefits, researchers also think that it seems to synergistically work with other cannabinoids, a term known as the entourage effect. This effect of THC and CBD working together is well-known, but whether other cannabinoids have entourage effects is not well understood.

CBC’s Medicinal Potential

The purported benefits of CBC have far-reaching implications. Below are a few medical conditions that may be alleviated by cannabichromene.

Cancer

Cannabichromene may be a powerful cancer fighter, and the reason might be its interaction with the body’s natural endocannabinoid, anandamide. CBC also appears to inhibit the uptake of anandamide, allowing it to remain longer in the bloodstream.

A recent study in which tumor growth was initiated in mice (two-stage mouse skin carcinogenesis model) showed cannabinoids might be effective in inhibiting both inflammation and tumor growth. Since anandamide has been shown to fight breast cancer in vitro and in vivo, this shows promise that CBC and other cannabinoids might one day be a chemopreventive agent.

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CBC as a potential cancer fighter was first published in a 2006 study that looked at cannabinoids other than THC and their possible effects on cancer. While THC is known for its anti-tumor properties for several different forms of cancer, its powerful psychotropic qualities can make it difficult for chemotherapy use. So far, research has found CBC to be the second-most-potent cannabinoid at inhibiting the growth of new cancer cells (CBG was the most potent).

Pain and Inflammation

Cannabichromene has been shown to block pain and inflammation associated with collagen-induced osteoarthritis. Cannabinoids like CBC act on inflammation differently than non-steroidal anti-inflammatory drugs (NSAIDs) do, and don’t have the side effects of these medications. In another example of the entourage effect, CBC in combination with THC had significant anti-inflammatory response in a recent animal study; together, the two cannabinoids produced a much greater effect on inflammation than by themselves.

Brain Cells

In a 2013 mouse study, CBC had a positive effect on neural stem progenitor cells (NSPCs), a cell essential to healthy brain function. NSPCs became more viable when in the presence of CBC, and that shows promise because NSPCs differentiate into astroglial cells, the most important cells for maintaining brain homeostasis. The astroglial cells perform a whole host of functions, including neurotransmitter direction and defending against oxidative stress. Astroglia counteract many of these issues—oxidative stress, inflammation, toxicity—that create neurological diseases and brain pathologies like Alzheimer’s disease.

A research team that had previously shown CBD’s effect on acne studied other cannabinoids, including CBC, for the same effects. Indeed, CBC was shown to be a powerful inhibitor of acne. As a skin disease, acne is characterized by excess sebum production and sebaceous gland inflammation. It turns out that CBC exhibited powerful anti-inflammatory properties and also suppressed excessive lipid production in the sebaceous glands. CBC also reduced levels of arachidonic acid (AA), which is needed to create the lipogenesis. More research is needed, but CBC might just one day become a very powerful anti-acne treatment.

Depression

In another amazing display of the entourage effect, CBC appears to work in conjunction with both THC and CBD to deliver a trifecta of antidepressant properties.

The therapeutic promise of CBC is important and requires more research to determine its power by itself as well as with other cannabinoids working together for an entourage effect. Cannabis patients today are limited in the products available to them, but hopefully as new studies emerge and cannabis laws loosen, new medicines with a diversity of cannabinoids will soon become an option.

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What is CBC?

By now you’re probably familiar with cannabinoids, especially the most common compounds THC and CBD. Maybe you’ve even tried CBG , but you likely haven’t heard of cannabichromene, also known as CBC.

What is cannabichromene?

Discovered over 50 years ago, CBC is considered one of the “big six” cannabinoids prominent in medical research. It doesn’t get as much attention, but CBC’s benefits are extremely promising.

CBC has the same origins as THC and CBD. They all stem from cannabigerolic acid (CBGa). Cannabis plants produce CBGa, the precursor to other major cannabinoids including tetrahydrocannabinolic acid (THCa), cannabidiolic acid (CBDa), and cannabichromenic acid (CBCa). These are cannabinoids with an acidic tail. With heat, the molecules transform into THC, CBD, and CBC.

CBC Effects

CBC OIL BENEFITS

While CBC has singular benefits, researchers believe it works synergistically with other cannabinoids in a phenomenon known as the entourage effect. It’s well-known that CBD and THC enhance each other’s power, but how other cannabinoids play into the entourage effect is not fully understood. However, the purported benefits of CBC have far-reaching implications. So what exactly is CBC oil good for?

CBC RESEARCH

CBC may be beneficial because of how it interacts with the body’s natural endocannabinoid anandamide. Anandamide produces a host of positive functions, most notably mood enhancement and fear reduction. CBC appears to inhibit the uptake of anandamide, allowing it to remain longer in the bloodstream, thus enhancing mood.

In another amazing display of the entourage effect, CBC appears to work in conjunction with THC and CBD.

CBC is important and requires more research to determine its power by itself, as well as with other cannabinoids working together for an entourage effect. Cannabis patients today are limited in the products available to them, but hopefully, as new studies emerge and cannabis laws loosen, researchers can hone in on the specific benefits of each cannabinoid.

WHAT IS CBC EXTRACTION?

CBC extraction is the same process as CBD extraction except with cannabichromene-rich hemp. First, producers pull the raw hemp oil from plant material using CO2. It’s then winterized (separated from unwanted plant material) and decarboxylated (heated to remove the molecule’s carbon tail). Because there is far less CBC in hemp than CBD, extracting CBC is more of a challenge, and most cannabichromene formulas maintain a generous amount of CBD.

Unlike CBG, CBN and CBD, cannabichromene does not chemically crystallize into a powdered isolate . Instead, distillate is the most concentrated form of CBC extract.

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Each cannabinoid has its own boiling point, which allows the distiller to separate cannabinoids using vacuum pressure and heat to extract a distillate. While distillate is the closest possible version of pure CBC oil, cannabichromene distillate contains a minuscule amount of other cannabinoids.

Our CBC Products

Cannabichromene

Relief Formula CBC Tincture

Bulk CBC Distillate

CBC PRODUCTS

Relief Formula CBC Tincture
We are one of the few companies that offer CBC tincture, which contains a 1 to 3 ratio of CBC to CBD. That’s 600 milligrams of CBC and 1800 milligrams of CBD in each 30-milliliter bottle. Unlike edibles, tincture results in quicker effects due to sublingual bioavailability.

Relief Formula CBC Softgels
Like our tincture formula, CBC softgels contain the same dose of CBC to CBD in each bottle (600 to 1800, respectively). Capsules possess a few benefits, mainly that softgels are pre-dosed, travel-friendly and tasteless.

CBC Chocolate Bar
Made by our partners at Peak Extracts in Oregon, the CBC chocolate bar contains 75 milligrams of Extract Labs CBD and 19 milligrams of CBC per bar. The broad spectrum edible is THC free.

Bulk CBC Distillate
As mentioned earlier, THC free distillate is an extraction with a high concentration of CBC cannabinoids. It’s the closest CBC will get to isolate because it cannot chemically convert into a solid. Bulk distillate comes in 5, 25, and 100 grams.

CBC Sauce
For a single portion of distillate, sauce is a ready-to-use syringe infused with Lemon Fuel cannabis terpenes . The strain is a Sativa-dominant hybrid. Dab sauce as it or add it to cannabis products, flowers, food, and other ingredients.

Adding CBC Cannabinoids to Your Regimen

When starting a plant-based wellness routine, it is important to try new things and listen to your body every step of the way. While CBD may be doing the trick on its own, you may find that experimenting with cannabinoids like CBC leads to better results.

If you have been trying different products to no avail, our team of in-house experts is on standby, ready to answer any and all questions. Whether you are just starting out and looking for answers on what to expect or a CBD expert just looking to refine your routine, we are here!

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