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Because CBD doesn’t produce the high associated with THC, it’s potential for abuse is considered limited by scientists. A March 2017 study published in the Journal of Drug and Alcohol Dependence examined details of a previous study where researchers administered various oral dosages of CBD to frequent marijuana users alone and in combination with smoked marijuana. The researchers determined that CBD had as much likelihood for abuse as the placebo in this study.

CBD has also demonstrated the potential to curb the use of other addictive substances. In a preclinical animal study published in Neuropsychopharmacology on March 22, 2018, researchers applied CBD gel to lab rats that had a history of voluntary alcohol or cocaine use and showcased addiction-like behavior. The study concluded that CBD was effective in reducing drug use in the rodents, and also reduced common side effects of drug dependency, such as anxiety and impulsivity.

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It’s possible to avoid THC when using a CBD product but the combination of CBD and THC is known to produce an entourage effect, boosting therapeutic benefits while subduing negative side effects. For instance, in a 2010 study involving patients with cancer pain, researchers found that the combination of THC and CBD was more effective in treating the pain than the THC and placebo combination.

One other area of concern is the potentially adverse effect that CBD could have on certain prescription medications such as blood thinners.

Marijuana-derived CBD is extracted from marijuana plants that are usually grown for their intoxicating properties. Unlike hemp-extracted CBD, marijuana-derived CBD oil often contains levels of THC that exceed the federal 0.3% limit. In the event the CBD oil has particularly high levels of THC, an individual could possibly experience cannabis withdrawal symptoms if the oil was used to excess. CBD oil with THC levels above 0.3% is only available in states with medical or adult-use cannabis legalization.

The tricky part is calculating the exact amount of CBD per milliliter of oil. Some tinctures have concentrations of 1,500 mg per 30 mL, while others have 3,000 mg per mL (or more).

CBD oil contains CBD mixed with an inert carrier oil, such as coconut oil or hemp seed oil. The bottled oil, called a tincture, is sold in various concentrations. There are also CBD capsules, CBD gummies, and under-the-tongue CBD sprays.

To determine an exact dose of CBD, remember that each drop of oil equals 0.05 mL of fluid. This means that a 30-mL bottle of CBD oil will have roughly 600 drops. If the concentration of the tincture is 1,500 mg/mL, one drop would contain 2.5 mg of CBD (1,500 mg ÷ 600 drops = 2.5 mg).

How to Calculate CBD Dose

Many of these interactions are mild and require no adjustment to treatment. Others may require a drug substitution or the separation of doses by several hours.

There is currently no known “correct” dose of CBD oil. Depending on individual needs and what is being treated, the daily dose may range between 5 and 25 mg.

In all but a few studies, lower doses of CBD (10 milligrams per kilogram, mg/kg, or less) improved some symptoms of anxiety. Higher doses (100 mg/kg or more) exhibited virtually no effect.

Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health.