Can I Give My Dog Melatonin And CBD Oil


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What is Melatonin and How Does it Work? What Are the Uses of Melatonin for Dogs? Is Melatonin Safe for Dogs? Potential Melatonin Side Effects to Look Out For! Dogs That Shouldn’t Take Melatonin How Much Melatonin for Dogs? Alternative Solutions: Innovet Pet Melatonin Overdose in Dogs Final Thoughts on How To Give Melat CBD may be beneficial in alleviating numerous health issues, as well as anxiety, fear, and insomnia, and does not have xylitol, which some melatonin supplements may have. Xylitol is toxic to dogs! Can Dog CBD interact with other medications that they're taking? Will it have a negative impact or create a great combo for our dog's health?

Melatonin for Dogs: Safe Uses and Latest Natural Alternative

If you’ve ever had issues sleeping, you’ve likely come across melatonin. It’s a popular all-natural supplement used for treating insomnia. Many animals naturally produce melatonin to regulate their sleep.

But better sleep at night isn’t the only thing that melatonin helps with. From improving mood to treating Cushing’s Disease to helping with hair loss, melatonin is a pretty nifty little chemical compound that may treat dogs that suffer from a wide range of medical conditions.

Check out our awesome guide below for everything you need about melatonin for dogs.

What is Melatonin and How Does it Work?

Melatonin is a naturally occurring hormone produced in the pineal gland that’s located in the middle of the brain. All mammals produce melatonin, and it helps our bodies with the sleep-wake cycle by telling us when we should be tired and when we shouldn’t.

Once night starts rolling around, the pineal gland will start producing the naturally occurring hormone thanks to signals the brain sends to it. As you can guess, once the morning sun pops up, the brain stops signaling to the pineal gland and melatonin production greatly slows down – causing your body to feel more awake.

Melatonin is key to sleep, and when melatonin production is disrupted, you’ll find that you may not fall asleep or stay asleep for enough hours. Most dogs need at least 10 hours of sleep, and just like us, not getting sleep will make them sick. By taking a melatonin supplement, dog owners and their dogs can benefit from synthetic melatonin that works as a hormone supplement to what your body naturally produces. The melatonin dosage will depend on your pet’s weight.

We all know how awful we feel when we don’t sleep well at night. We can become angry, irritable, stressed, and anxious, and feel too weak to fight these nasties away.

Just as it happens in humans, all of this may happen to your canine.

What Are the Uses of Melatonin for Dogs?

Because both us and our pups produce melatonin in our bodies, it’s safe to give melatonin to your dog, and the supplement may help them in the same way it helps us through several medical conditions and cognitive disorders and improve your pet’s health and help your dog relax. There are other medications that work as sleep aids. However, many vets prescribe melatonin as the first course of action to improve dog sleep.

Cushing’s Disease

Cushing’s Disease affects both humans and dogs and can cause weight gain, fatty deposits around the midsection, and thin skin that easily bruises. It’s caused by pituitary tumors called adenoma. While not cancerous, these tumors create a hormonal imbalance by causing the pituitary gland to release too much ACTH which stimulates the production of the hormone cortisol.

Cortisol, better known as the stress hormone, is incredibly stressful on the body, and chronic production results in muscle weakness, diabetes, along with the issues mentioned above. We can secrete cortisol anywhere from eating different food to having a tough day.

There are conventional treatment options for treating Cushing’s Disease, but some dogs may experience side effects. This is why some pet owners may be interested in using melatonin supplements along with flaxseed lignans as they are used to treat high cortisol levels without causing side effects.

Both melatonin and lignans inhibit different enzymes used in cortisol production. They also target adrenal tumor cells allowing them to treat all forms of Cushing’s Disease.

General Anxiety and Separation Anxiety

Dogs and anxiety go together like kids and candy. Whether it’s fireworks, thunderstorms, you leaving the house, or the neighbor’s dogs, it seems like there is always something that freaks out every dog.

Anxiety melatonin supplements may also help keep your dog calm without sedating them as some anxiety meds do. Mix in a supplement with their favorite food and your pup can say goodbye to that increased heart rate.

Sleep Problems

Melatonin supplements may be used to treat and support dogs struggling with insomnia and improve cognitive function regardless of whether they have low melatonin levels. If they aren’t deficient, the extra melatonin will still promote tiredness.

If your dog is deficient in melatonin, then supplementing it may help regulate their circadian rhythm – the natural 24hr sleep-wake cycle.

Hair Loss and Alopecia

If you notice that your dog is losing too much body hair during certain times of the year or you see thin hair and patches, melatonin can help. Alopecia is hair loss that isn’t allergy-related. Scientists aren’t sure just how it works – yet – but studies show that melatonin can assist dogs who suffer from alopecia to regain their hair.

Is Melatonin Safe for Dogs?

Because most animals naturally produce melatonin, giving it to your dog is completely safe and comes with few side effects. Now, there are a few things you’ll watch out for, however.

First, if you are thinking about using melatonin to treat a medical condition such as Cushing’s Disease then talk to your veterinarian. They will help you determine what the best approach is for treating the disease. A trusted veterinarian will support you and answer any questions.

Second, you always want to make sure you are giving your dog the appropriate dosage based on their weight and age. Always be sure to give their dose with food to prevent digestive problems or stomach aches.

Potential Melatonin Side Effects to Look Out For!

The most common side effects are drowsiness and fatigue. If you notice that your dog is slowly getting up in the morning, then you may want to reduce its dosage.

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Watch out when giving it to dogs that are diabetic as melatonin may cause insulin resistance and other side effects.

Make sure the melatonin does not contain xylitol as it is toxic to dogs. As well, there is always a small chance your dog could have an allergic reaction so look for any sign of a reaction the first few times after administering.

Last, people have reported that their dreams are more intense when taking melatonin. It’s likely that this extends to dogs as well.

Dogs That Shouldn’t Take Melatonin

There are two cases where you want to be careful giving melatonin to your dog. First, the use of melatonin may not be appropriate for dogs that are diabetic as it can increase insulin resistance.

To search for more information, we found a 1999 study published out of the University College London that showed that melatonin decreased levels of sex hormones in both male and female dogs. As such, you may not want to give your dog melatonin if they are currently being used for breeding. You’ll want to talk to your veterinarian about giving pregnant dogs melatonin just to be sure.

What To Do When Your Dog Shows Negative Melatonin Effects

Again, it extremely rare to see negative, but evidence shows melatonin may have some adverse effects. If you notice a sign that all is not right, then immediately seek help from your vet and have them treated.

How Much Melatonin for Dogs?

After hearing about how awesome melatonin for dogs is, you’re probably wondering how much you should give them.

Again, it’s best to work with your vet when nailing down the correct dosage of melatonin supplement for your dog. While their weight will be one of the biggest factors, the medical condition you are using melatonin for will play a role.

In general, you can follow this guide:
  • 9 pounds and under = 1 mg
  • 10 to 25 pounds = 1.5 mg
  • 26 to 100 pounds = 3 mg
  • 100 and up = 3 to 6 mg

You can give this dosage 1 to 3 times a day with food to avoid any digestive complications.

For disorders like anxiety, depression, or phobias it’s common to only administer melatonin when treatment is needed.

For sleep-related issues, everyday use is generally recommended.

Alternative Solutions: Innovet Pet

Many pet parents are on the search for stronger over-the-counter veterinary supplements with a low risk for treating anxiety then check out our CBD blog. Many pet owners are finding that CBD products can help their dogs with anxiety, pain, sleep, and epilepsy.

At Innovet Pet, we offer CBD veterinary supplements in several great forms from easy-to-use tinctures to yummy food that your pet simply can’t resist.

Using a CBD supplement in tandem with melatonin can extend its health benefits and better help dogs that struggle to sleep because of pain, old age, inflammation, etc. So if you’re looking to improve your pup’s health across the board, check out Innovet Pet’s great line of Hemp CBD products.

Melatonin Overdose in Dogs

As with most medications, if you notice an adverse reaction after giving melatonin to your dog, you will need to contact your vet right away. As well, make sure to keep a close eye on them the first few times they’re treated to make ensure they don’t have an allergic reaction to melatonin.

Here are some tips on using melatonin for dogs:

  1. Make sure your melatonin doesn’t contain xylitol
  2. Buy from a trusted brand and make sure to check online reviews.
  3. When discussing how much melatonin you can give with your vet, ask them what brand they recommend.
  4. Look for melatonin formulated and approved for dogs.

Final Thoughts on How To Give Melatonin To Dogs

When used properly, dog melatonin helps your dog get a better night’s sleep and feel calmer throughout the day. When combined with another natural anxiety and sleep aid like CBD, there is a great chance that your dog won’t have to go on other medications that could have nasty side effects.

However, be sure to talk with your vet before trying any new health supplements.

For more great health tips and learning how to give your pets possible, make sure to check out our blog. We regularly update it so you can stay up to date with all that’s happening in the pet health world.

CBD as an Alternative Supplement to Melatonin

If your dog is having problems sleeping, melatonin or CBD may be the answer. Both can help with Cushing’s Disease, noise phobia, as well as separation anxiety. That said, a healthy alternative to melatonin for dogs is CBD oil.

CBD may be beneficial in alleviating numerous health issues, as well as anxiety, fear, and insomnia, and does not have xylitol, which some melatonin supplements may have. Xylitol is toxic to dogs!

What is Melatonin?

The Merck Veterinary Manual explains that “ Melatonin is produced in the pineal gland and is involved in the control of photoperiod-dependent molting of some mammals. Secretion is inversely related to daylight length and is highest during the winter. Various canine hair-growth disorders including recurrent flank alopecia, pattern baldness, and excessive trichilemmal keratinization have improved with melatonin supplementation. Recurrent flank alopecia may be treated with 36-mg SC implants. Oral melatonin is also available; an empirical dosage of 3–6 mg/dog, tid-qid, has been used successfully.”

Melatonin is a natural hormone and supplement and affects sleep in dogs and people. It is synthesized from the amino acid tryptophan in the pineal gland at the back of the brain. You can also find melatonin in some foods. It is a safe and natural supplement that regulates sleep and wake cycles, and also helps to support normal immune function in pets and people. Melatonin also has the potential to protect cells against free radical damage.

What is CBD?

CBD (cannabidiol) is a component of the cannabis plant, but without the tetrahydrocannabinol, (THC), the component of the cannabis plant that gives you the “high”. With no THC, there is no psychoactive reaction.

  • CBD comes from the hemp plant, but can also be extracted from the cannabis plant. CBD oil is the liquid that comes from the cannabis plant, with the best form of extraction being the CO2 method.
  • Cannabidiol oil for dogs may be beneficial for many health problems in dogs including cancer, arthritis, to stimulate appetite, and may also help treat tumors, and ease anxiety and depression.
  • Tetrahydrocannabinol, most often referred to as THC, is the psychoactive compound that is derived from the cannabis plant. It is responsible for the “high effect”, and is federally regulated in the U.S, yet is legal in Canada for recreational and medicinal use, and also in some US states.
  • Hemp has higher levels of CBD and low levels of THC. For hemp to be classified as such, it has to contain only 0.3% of THC. 0.3 % THC yields no “high” effect. Hemp was made federally legal in the US through the Farm Bill in 2018.
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CBD offers numerous other health benefits

We love our dogs and want them to feel relaxed and happy. So far, CBD has demonstrated numerous health benefits with little to no side effects. The latest 2019 pilot study on the benefits of Cannabis oil for dogs by the Colorado State University’s James L. Voss Veterinary Teaching Hospital demonstrated that “ scientists have found in a small study that 89 percent of dogs who received CBD in the clinical trial had a reduction in the frequency of seizures. Nine dogs were treated with CBD, while seven in a control group were treated with a placebo.” via Science Daily. We are learning new things every day about the benefits of this natural supplement.

The following are some of the important findings to date from in vitro and animal studies:

  • CBD affects the growth of tumoral cell lines but has no effect in most non- tumor cells. However, a pro-apoptotic effect has been observed in lymphocytes.
  • It has no effect on embryonic development (limited research)
  • Evidence on potential hormonal changes is mixed, with some evidence of possible effects and other studies suggesting no effect, depending on the method used and the particular hormone
  • It has no effect on a wide range of physiological and biochemical parameters or significant effects on animal behavior unless extremely high doses are administered (eg, in excess of 150 mg/kg iv as an acute dose or in excess of 30 mg/kg orally daily for 90 days in monkeys)
  • Effects on the immune system are unclear; there is evidence of immune suppression at higher concentrations, but immune stimulation may occur at lower concentrations.
  • There is potential for CBD to be associated with drug interactions through inhibition of some cytochrome P450 enzymes, but it is not yet clear whether these effects occur at physiological concentrations.
  • CBD was also not associated with abuse potential

According to a study, CBD may also be beneficial for depression in pets. The study adds that “cannabidiol (CBD), the main non-psychotomimetic component of marihuana, exhibits anxiolytic-like properties in many behavioral tests, although its potential for treating major depression has been poorly explored.”

Benefits of melatonin for dogs

  • Melatonin may be beneficial for certain anxiety issues, sleep disorders, and neurological problems in both people and pets.
  • Melatonin is available in a capsule or tablet form.
  • It helps with hair growth in dogs.
  • It may be effective for thunderstorms and noise phobia issues.
  • You’ll need to consult with your vet for any side effects with other meds before using them.
  • Melatonin is a safe and natural supplement and is a safe alternative to traditional pet meds that may have side effects.

According to a 2018 study published in the American Veterinary Medical Foundation (AVMA), 20% of dogs suffer from anxiety. Dr. Daniel Mills, DVM, and a professor of veterinary behavioral medicine at the University of Lincoln, School of Life Sciences in England, adds that “ Separation anxiety has several distinct forms based on a mixture of emotional and motivational states, he said. About 20 percent of dogs are affected. Consistently across studies, he said, 15 percent of dogs aren’t responding to medication, and 15 percent aren’t responding to behavioral treatment.”

Melatonin adverse reactions

If you’re worried that your furry best friend has experienced an adverse reaction or that you may have administered the incorrect dosage, consult with your veterinarian. What’s important is to never double up on a missed dose. As with all meds, veterinarians recommend waiting until the next succeeding dose so that your dog does not experience an adverse reaction.

CBD as an alternative solution for some shut-eye or anxiety relief

We all want our dogs to be healthy and stress-free, and would much rather give them natural supplements to traditional meds. Since there are no long term side effects with either CBD or melatonin, you’ll need to examine both supplements to see which one is best for your pet. When looking for an alternate supplement for sleep relief or anxiety, you’ll also need to consult with your vet to make sure that your dog has no underlying health issues.

A 2019 CBD study about CBD for dogs with insomnia added that ‘ On average, anxiety and sleep improved for most patients, and these improvements were sustained over time. At the first monthly assessment after the start of CBD treatment, 79.2% (57/72) and 66.7% (48/72) of all patients experienced an improvement in anxiety and sleep, respectively; 15.3% (11/72) and 25.0% (18/72) experienced worsening symptoms in anxiety and sleep, respectively. Two months after the start of CBD treatment, 78.1% (32/41) and 56.1% (23/41) of patients reported improvement in anxiety and sleep, respectively, compared with the prior monthly visit; again, 19.5% (8/41) and 26.8% (11/41), respectively, reported worsening problems as compared with the prior month,” via NCBI.

CBD for Dogs And Its Interaction With Other Medication

Dog CBD interaction is a reaction between CBD and the other drug your dog is taking. These days, more and more people are now including CBD in their dog’s everyday life.

However, is CBD oil interacting with other medications okay? Below, we’ll tackle if dog CBD can have a negative side effect on dogs taking other medication.

The benefits of CBD are great and are a safe supplement in general. However, will it complement other medications? Well, it depends on the drug they are taking.

Dog CBD Interaction with Medications

CBD and Rimadyl interaction for dogs

Rimadyl is a Non-Steroidal Anti-Inflammatory Drug or NSAID. NSAIDs are a class of drugs prescribed to manage pain or reduce inflammation in dogs.

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Studies have shown that it doesn’t have any drug interaction with CBD. But that doesn’t mean it will not exist in the future.

In this case, dog CBD interaction will depend on the dog’s body chemistry and the dosage of CBD or Rimadyl. CBD can help maintain the dog’s well-being and balance with proper dosage.

CBD and Melatonin Interaction for Dogs

What even is Melatonin? Melatonin is a hormone released by the pineal gland in the brain that helps regulate the dog’s sleep and even waking up.

The powerful combination of CBD and Melatonin helps the dog’s wellness support. Some of the benefits found in CBD and Melatonin provide the same effects for your dogs.

CBD is known for its calming properties. Melatonin, on the other hand, provides comfort and restful sleep. This combo can work together to help maintain the dog’s well-being and proper rest.

CBD and Benadryl for Dogs

Benadryl is an antihistamine that is given to dogs that experience allergy symptoms.

It is usually prescribed by vets to treat environmental allergies or allergies caused by insect bites or stings.

It works by blocking the histamine (H-1) activity that causes allergic symptoms on a dog’s body. There is no known interaction between Benadryl and CBD.

But there can still be risks. CBD and Benadryl are both metabolized through the cytochrome P450 Enzyme System. This can increase the chances of doubling the side effects of both CBD and Benadryl.

It can potentially cause severe drowsiness or fatigue. We suggest checking with your vet before combining these two.

CBD And Glucosamine Interactions

CBD and Glucosamine can be an excellent combination for a dog that suffers from joint problems like arthritis or joint pain in general.

Glucosamine is one of the most popular over-the-counter arthritis medicines. It is usually given to manage pain on the joints caused by hip dysplasia. Glucosamine can also help with the treatment of spinal disc injury.

With the two-punch combo of CBD and Glucosamine, it can help reduce pain and inflammation from your dog’s joints.

CBD and Prednisone for Dogs

Dog CBD interaction with Prednisone is not recommended for dogs. Prednisone is a prescription steroid used to reduce inflammations, treat allergy symptoms, arthritis, and more.

CBD and Prednisone together are not recommended for dogs as they can increase the side effects of both. They are both inhibitors of the CYP450 Enzyme System.

If you’re planning to give CBD oil to your dogs while they are on different medications, it is best to consult with your vet in these situations.

CBD and Meloxicam Lethal Combo for Dogs

Meloxicam, likewise Rimadyl, is a Non-Steroidal Anti-Inflammatory Drug or NSAID. Meloxicam is prescribed as a pain killer that helps ease inflammation in dogs.

There is a chance that taking NSAIDs with CBD can increase the effects of these pain killers. It all comes down to proper dosage on meds and supplements.

You, as the owner, have the responsibility to research, talk to your vet, and monitor your dogs when taking the CBD route in addition to meloxicam.

Commonly Asked Questions

Will Benadryl help with Dog Anxiety?

Well, yes and no. You have to identify what kind or cause of their anxiety.

Benadryl can help reduce dog anxiety symptoms. It is also used as a sedative to help dogs during fireworks, thunderstorms, or traveling. But overall, Benadryl is not helpful for dogs struggling with anxiety or phobias.

It has high efficiency in helping dogs with motion sickness. However, it can have opposite side effects on rare occasions where your dogs will be hyperactive rather than sedated.

Proper Dosage of Benadryl for Dogs

Giving dogs about 2-4mg of Benadryl for every kilogram of body weight is good. However, it is still best to consult with your vet and wait for their approval before you take action.

Administering the correct dosage of Benadryl for dog anxiety is crucial. The wrong amount can have serious consequences.

How often do I give CBD oil to my dog?

This all depends on the dog’s condition. Some dogs can benefit from daily doses, and others can not.

For example, dogs suffering from arthritis or seizures can benefit from a daily or twice a day dose of CBD between 2-8mg/kg or lower. An interval of eight to twelve hours is advised when CBD twice a day.

A good rule of thumb when administering CBD oil for your dog is 1-5mg CBD for every 10 pounds of their body weight.

What happens if your dog takes too much CBD?

CBD is a non-toxic and non-psychoactive compound meaning it will not get ‘high’. However, when taken too much intense, concentrated CBD, potential side effects can develop.

A few of these symptoms are lethargy (lack of energy), vomiting, drowsiness, urinary incontinence, and hypersensitivity.

Dog CBD Interaction with other Medication Summary

Due to a lack of research, there are still many things that we don’t yet know about the world of CBD, not just for humans but also for dogs. But we cannot deny the great benefits of CBD for dogs.

When giving CBD to our dogs, there are still many things to consider. We must focus not only on the correct dosage but also on other medications that they need.

Studies showed that CBD has no known interaction with medications, but it doesn’t mean it will stay like that. Dog CBD interaction will depend on the dog, CBD, and the medicine.

Our vets usually prescribe these medicines. It is still the best choice to consult with your vet in CBD drug interactions.

Since the FDA doesn’t regulate CBD products yet, most US Veterinary and Pharmacy boards are advised to avoid prescribing or discussing CBD until further notice.

Always remember that you are the one in control when it comes to CBD oil drug interactions.

You have the power to help your dogs maintain a well-balanced life. Research, consult with your vet, and monitor.

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